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TERNOPIL STATE MEDICAL UNIVERSITY

June 13, 2024

TERNOPIL STATE MEDICAL UNIVERSITY

By I.Ya. Horbachevsky

“Approved”

Vice-rector for education & training

_________Professor Ihor R. Mysula

“_____” ___________________ 2008

WORKING PROGRAM

from the clinical pharmacology

pharmacology chair with the clinical pharmacology

Speciality (Dentistry, 7.110106)

The

year of study

Hours quantity, In the average

Lectures

Practical classes

ISW

The type of assessment

–

test

Matricul of practical skills

13,2

Made the program: assistant prof. V.M .Meretskyy

The program discusses at the chair sitting:

“__11_”06_____2008, Minutes № _13____

The Head of the Chair _______________ prof. K.A.Posokhova

Program is authorized by the Cycle Methodological Commission sitting of SSI pharmacology, hygiene and medical chemistry by M.P. Skakun

“__19_”_06_2008, Minutes № 5___

The Head of cyclic methodical commission ___________Oleshuk О.М.

TERNOPIL 2008

EXPLANATORY MESSAGE AND DISCIPLINE STRUCTURE

On determination of WHO (1971) clinical pharmacology – science, that occupies by the study of medications in application to the person. Clinical pharmacology – integrative region of clinical medicine, that is based on achievements of theoretical pharmacology, progress of medicine and clinic of inner illnesses. This science stages by its aim to arm a doctor by knowledges, that allow to choose the most effective and safe medicinal mean for determine sick person, taking into account basic and concomitant diseases. The task of teaching a clinical pharmacology consists in teaching students of influence of medications on organism of sick man, processes of suction, distribution, bіоtransformation and selection of medical matters, study of indirect action of medicines, action features and influence of different states of organism (age, pregnancy, disease) on sensitiveness to medicines, co-operations of different preparations, in case of their compatible purpose.

One of the most important tasks of study of clinical pharmacology there is forming at students of clinical thinking in the relation of use of medications for the medical treatment concrete sick.

At analysis sick person on the clinical and thematic rounds the student must learn to give the answers on the following questions:

1. Which concrete changes in state of sick person does he want to attain?

2. Which medications can assist to achievement of this desired effect?

3. Which preparation does most befit for this sick person?

4. How to apply best of all preparation?

5. Which still effects can cause this drug? Whether will not it harm sick man?

6. As far as supposed positive effect does the possibility of damage prevail actions?

7. Which correlation of benefit and risk in case of application of this preparation?

In the process of teaching the students must learn to have by method of clinical pharmacological thinking, which is based on the fundamental knowledge of both clinical medicine so experimental pharmacology, to write the recipes, constantly to meet with appearance of new medications of both home so oversea, production.

2. AIM OF STUDY OF EDUCATIONAL DISCIPLINE

Course aim there is a capture by knowledges of pharmacokinetic and pharmacodynamic, co-operation and indirect action of basic groups of medications, their change, at pathology of different organs and systems and rational choice of agents for conducting modern individualize pharmacotherapy.

3. PROGRAM TABLE OF CONTENTS

The program includes 2 sections: commons and applied aspects of clinical pharmacology.

GENERAL QUESTIONS OF CLINICAL PHARMACOLOGY.

The general section exposes a systems approach to the study of discipline, gives presentation about object, aim of its study, tie, with others sciences and practical activity of doctor.

Aim of general section: to secure motivation for perception and mastering by students of concrete material on the special questions of clinical pharmacology.

Tasks of general section:

· to present the integral system of theoretical bases of clinical pharmacology; factors, that assist to the origin of metabolism changes, actions of drugs, multiply a risk of development of indirect action;

· to set the ways of realization of basic questions of clinical pharmacology in sick;

· to study pharmacokinetic parameters of agents;

· to study pharmacodynamic parameters of agents;

· to estimate possibility of co-operation of preparations;

· to forecast the indirect action;

· to give notion about the system of pharmacological supervision in Ukraine and basic ways of decision of problem of warning complications in case of application of medicines;

· to study intercommunication of agents pharmacokinetic and pharmacodynamic ;

APPLIED ASPECTS OF CLINICAL PHARMACOLOGY

The clinical pharmacology of preparations that are widely used in the practical medicine lays out in this section.

Section aim: to give methodology of choice of groups and concrete agent taking into account data of pharmacokinetic, pharmacodynamic, co-operation and indirect action depending on state sick person.

Section tasks:

· to teach to conduct a selection most effective and safe drug;

· to determine the optimum mode of dosage, to choose a correct method of introduction taking into account the pharmacokinetic and pharmacodynamic parameters of medicines, and also age, sex, and clinical state sick person;

· to appoint an effective and safe combination of agents in the concrete clinical situation;

· to forecast and expose on the early stages the indirect action of agents and conduct its correction;

· to set clinical and paraclinical parameters of control of efficiency and action safety apply medicines;

· to determine most accessible and objective methods of control and frequency of their application;

· to take into account features of pharmacokinetic, pharmacodynamic of agents at the weak functionof cardiovascular, respiratory system;

· to take into account risk factors and clinical displays of indirect action of medicines at monotherapy and at combination with preparations of other mechanism of action.

These tasks there can be executing only in case of seizing by students of skills of clinical diagnostic thinking from the basic nosology units of pathology of man and fundamental disciplines (pharmacology, therapies, paediatrics, surgery, obstetric and gynaecology and others clinical disciplines).

THEMATIC PLAN OF PRACTICAL LESSONS

for stomatological faculty students

№

Practical Lessons

Hours

Theme 1. Clinical pharmacology of antianginal drugs -2 h. Theme 2. Clinical pharmacology of antihypertensive drugs – 2 h. Theme 3. Clinical pharmacology of cardiac glycosides – 3 h.

Theme 1. Clinical pharmacology of local anesthetics – 2 h. Clinical pharmacology of general anesthetics – 2 h. Clinical pharmacology of narcotic and nonnarcotic analgesics – 3 h.

Theme 1. Clinical pharmacology of non-steroid and other anti-inflammatory agents – 3 h. Theme 2. Clinical pharmacology of steroids – 3 h.

Theme 1. Clinical pharmacology of antibiotics – 2 h. Theme 2. Clinical pharmacology of antibacterial drugs – 2 h. Theme 3. Clinical pharmacology of antiviral and antifungal agents – 2 h.

Theme 1. Clinical pharmacology of antiseptics and enzyme drugs – 3 h. Theme 2. Clinical pharmacology of drugs with influence on metabolism in solid dental tissues (medicines with phosphorus, calcium and fluorine) – 3 h.

All

Head of Pharmacology

with clinical pharmacology

Prof. Posokhova Kateryna A.

THEMATIC PLAN

of independent student work from the clinical pharmacology

№

THEME

Hours

Clinical pharmacokinetics.

Indirect action of medications. Medicinal illness.

Clinical pharmacology of facilities, that affect the blood system

Clinical pharmacology of facilities, that regulate water-electrolyte and acid-base balance.

Clinical pharmacology of anticancer facilities.

Clinical pharmacology of facilities, that used in endocrinology

Clinical pharmacology of facilities which affect CNS

All

Head of Pharmacology

with clinical pharmacology

Prof. Posokhova Kateryna A.

LIST OF PRACTICAL SKILLS BORNE IN MATRICUL OF PRACTICAL SKILLS

Name of practical skill

Level of seize

Line of matricul

Authentication of known medications by means international, auction, name in relation to their belonging to the definite group.

To make an use normative and reference literature on the medical preparations.

To carry in the concrete clinical situation out choice of optimum medical preparations in every group, their medical form, dose and introduction ways.

Methods and criteria of estimation of clinical efficiency of medical preparations of basic groups.

To expose clinical signs of indirect action of medications.

To write medical preparations in recipes

4. QUESTIONS FOR THE SEMESTER TEST

1.Clinical aspects of pharmacokinetic medicines.

2. Clinical aspects of pharmacodynamic medicines.

3. Clinical pharmacological aspects of application of medical preparations in the different periods of life.

4. Medical preparations interaction.

5. Indirect action of medicines.

6. Clinical pharmacological description of preparations of group of nitrates.

7. 7 Clinical pharmacological description of b-blockers.

8. Clinical pharmacology of Ca⁺⁺Channel blockers

9. Clinical pharmacology of sydnonimines and activators of potassium channels.

10. Clinical pharmacology of antihypertensive facilities.

11. Clinical pharmacology of nonsteroidal anti-inflammatory drugs.

12. Clinical pharmacology of steroidal anti-inflammatory drugs.

13. Clinical pharmacology of digitalis glycosides.

14. Clinical pharmacology of nonglycosides inotropic facilities.

15. Clinical pharmacology of metabolic agents.

16. Clinical pharmacology of diuretics.

17. Clinical pharmacology of neuroleptics.

18. Clinical pharmacology of tranquilizers.

19. Clinical pharmacology of sedatives facilities.

20. Clinical pharmacology of antidepressants.

21. Clinical pharmacology of psychostimulators.

22. Clinical pharmacology of anticonvulsant facilities.

23. Clinical pharmacology of sleeping-pills.

24. Clinical pharmacology of neurometabolic facilities.

25. Clinical pharmacology of enzymic preparations.

26. Clinical pharmacology of iron preparations.

27. Clinical pharmacology of antiplatelet.

28. Clinical pharmacology of anticoagulants.

29. Clinical pharmacological description of thrombotic facilities.

30. Clinical pharmacology of thrombolytic facilities.

31. Clinical pharmacology of insulin preparations.

32. Clinical pharmacology of peroral antidiabetic facilities.

33. Clinical pharmacology of preparations of hormones of thyroidal gland.

34. Clinical pharmacological description of antithyroidal facilities.

35. Clinical pharmacology of preparations of hormones to the hypophysis.

36. Clinical pharmacology of vitamin preparations.

37. Clinical pharmacology of prostaglandins and their synthetic analogues.

38. Clinical pharmacology of medical preparations, that used for the medical treatment of oncologic diseases.

39. Clinical pharmacology of antibiotics.

40. Clinical pharmacology of fluoroquinolones.

41. Clinical pharmacology of sulfonamids.

42. Clininal pharmacology of nitrofurans, nitroimidazols.

43. Clinical pharmacology of antiviral drugs.

44. Clinical pharmacology of antimicoses facilities.

45. Clinical pharmacology of antituberculosis facilities.

46. Clininal pharmacology of analgesic facilities.

47. Clininal pharmacology description of facilities for anesthesia.

48. Clinical pharmacology of facilities, that regulate water-electrolyte and potassium-acid balance.

49. Basic principles of therapy of the sharp poisoning by the medical preparations, control after the indirect action of medicines.

5. CONTROL FORMS AND CRITERIA OF EVALUATION OF KNOWLEDGES AT THE END OF WORKDAY

The evaluation of practical part carries out after curation a patient (diagnosis, preparations which wrote out in recipes to concrete to sick, efficiency criteria, list of signs of credible indirect action). Estimation after 12 by the ball scale proposes to the student for activity during curation, plenitude of exposition of every section of protocol. The estimation after seminar lesson in part proposes after 12 by the ball scale the student activity, abstract preparation, abstract exposition, participation in the discussion, rightness of answers, in the decision of situation tasks. The writing part includes the 2 theoretical questions, situation task and 5 test tasks. The estimation of student of this part folds from sum of balls which was collected by student for every type of the supervisory program. So, for the 2 theoretical questions the student can get 20 balls, for the decision of situation task – 10 balls and 5 test tasks – 10 balls ( 2 ball after 1 test). Together 40 balls. In accordance to collect sum of balls after table the estimation proposes after 12 by the ball scale.