METHODICAL INSTRUCTION FOR STUDENTS OF THE ___ COURSE
Pharmaceutical Faculty
LESSON № 20 (PRACTICAL – 6 HOURS)
Theme: Asepsis. Requirements for the manufacture of sterile and aseptic medicines in pharmacies. Solutions for injections.
Aim: learn how to prepare solutions for injection without stabilizers, assess their quality, and design to dispense.
Professional orientation of students. Injection medical form by introducing drugs has several advantages, the main of which – the rate of therapeutic action, dosage accuracy, the possibility of entering a patient who is unconscious condition. This is explained need to examine this topic.
PRACTICAL CLASS
Student’s practical activities: 900 – 1200
Work 1.
Prepare medications and evaluate their quality. Pack powders, design them to dispense, write a written passport control.
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1. Rp.: Solutionis Natrii chloridi 0,9% 100 ml Da. Signa. For intravenous drip |
2. Rp.: Solutionis Natrii chloridi 10% 100 ml Da. Signa. 10 ml intravenously |
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3. Rp.: Solutionis Calcii chloridi 10% 100 ml Da. Signa. For 5 ml intravenously (use 20% solution concentrate of calcii chloridi) |
4. Rp.: Solutionis Calcii chloridi 5% 100 ml Da. Signa. 10 ml intravenously (use 20% solution concentrate of calcii chloridi) |
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5. Rp.: Solutionis Platyphyllini hydrotartratis 0,2% 30 ml Da. Signa. 1 ml hypodermic |
6. Rp.: Solutionis Kalii chloridi 0,5% 50 ml Da. Signa. For intravenous inflowing 10 ml |
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7. Rp.: Solutionis Kalii chloridi 1% 100 ml Da. Signa. 15 ml intravenously |
8. Rp.: Solutionis Dimedroli 1% 50 ml Da. Signa. 1 ml intramuscular 3 times on a day |
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9. Rp.: Solutionis Ephedrini hydrochloridi 1% 50 ml Da. Signa. 1 ml hypodermic |
10. Rp.: Solutionis Acidi borici 2,0% 100 ml Da. Signa. For treatment surgical weed. |
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11. Rp.: Solutionis Furacilini 0,02% 250 ml Da. Signa. For treatment of the opened wounds |
12. Rp.: Solutionis Aethacridini lactatis 0,1% 100 ml Da. Signa. For treatment of the opened wounds |
Tasks
Task № 1
For preparation injection solution used purified water. Is it possible?
Task № 2
Ready solution of sodium chloride pharmacist sterilized in autoclave at 120 °C 30 minutes. Is he elected regime sterilize?
Answer: When 120° C –8 minutes.
Task № 3
To stabilize the same volumes of 5% and 40% glucose solution pharmacist took different quantities of liquid Weybel. Is it possible?
Answer: liquid Weybel as stabilizer used in amounts of 5% according to the volume of glucose solution.
Tests
1. How long pharmacist need to sterilize 250 ml 5% glucose steam under pressure at a temperature of 120 °C ?
A. * 12 min.
B. 8 min.
C. 30 min.
D. 15 min.
E. 1 hr.
2. The pharmacy sterilized auxiliary materials. Specify the timing of their storage in aseptic conditions in a closed slut:
A. *no more than 4 days
B. no more than 3 days
C. no more than 5 days
D. no more than 6 days
E. 7 days
3. Patient was made injection solution. What is the reaction of the organism occurs when the introduction of injection solutions containing pyrogenic substances?
A. *increase in body temperature
B. bleeding
C. high blood pressure
D. drop in blood pressure
E. dehydration
Seminar discussion of theoretical issues: 1230 – 1400
1. Dosage forms, which are prepared under aseptic conditions.
2. Characterization of injection medical forms, requirements for them.
3. Advantages and disadvantages of injection medical forms.
4. Aseptic terms of preparing drugs for parenteral use.
5. Methods of sterilization and equipment used for it.
6. Characterization of solvents used for preparing injection medical forms.
7. Receiving, storage and control the quality of water for injection according to State Pharmacopoeia.
8. Technology of solutions for injection.
9. Evaluation of the quality of solutions for injectionpackaging, design to dispense, and storage conditions according with the requirements of NTD.
Student should know:
1. Dosage forms, which prepared under aseptic conditions, their characteristics, requirements.
2. Aseptic terms of preparing medicines.
3. Methods of sterilization, equipment.
4. Characterization of solvents used for preparing injection medical forms.
5. Receiving, storage and control the quality of water for injection according to State Pharmacopoeia.
6. Technology of solutions for injection.
7. Assessment of quality of solutions for injection, closing, processing and storage in accordance with the requirements of technical documentation.
Student should be able to:
1. Evaluate prescriptions are correct and to verify the dose of toxic and strong affective substances in solutions for injection
2. Using the State Pharmacopoeia, other regulatory documentation and reference literature to find the necessary information for preparation injection solutions with stabilizations.
3. Calculate the amount and medical substances for the preparation of these solutions.
4. Choose the best option taking into account the technologies of physical and chemical properties ingredients and equipment, which is in existence.
5. Provide sanitary and hygienically conditions for aseptic preparation solutions for injection.
6. Use the basic technological operations for preparing injection medical (to weigh out, to dissolve, to filter, to carry out control on absence of mechanical inclusions, hermetically to close, to design to sterilization, sterilize).
7. Observe rules of safety equipment during work with cameras for filtration, sterilization and control of purity injection solutions.
8. Use minor mechanization during preparing injection solutions (bactericidal lamps, filter setting sterilizes, corking of small bottles etc).
9. Quality control of prepared solutions. Bottle and design medical preparations to dispense.
10. Write written passport control.
А – Basic:
1. Pharmaceutical Compounding and Dispensing.-Pharmaceutical Press,
2. European pharmacopoeia. Sixth edition. Council of Europe. Strasborg– 2007.
http://downloadspharmacy.blogspot.com/2011/08/european-pharmacopoeia-free-download_9561.html
В – Additional:
1. Pharmaceutical Manufacturing Handbook: Production and Processes (Pharmaceutical Development Series) Wiley-Interscience; 1 edition (March 21, 2008), 1384 pages.
2. Pharmaceutical Powder Compaction Technology, Second Edition (Drugs and the Pharmaceutical Sciences) Informa Healthcare; 2 edition (May 11, 2011), 600 pages.
3. The Art, Science, and Technology of Pharmaceutical Compounding [American Pharmacists Association (APhA); 3 edition (March 15, 2008), 556 pages.
4. Pharmacy Technician Certification Exam Review, 3rd Edition .Lorraine C. Zentz .ISBN-10: 1428320628 ISBN-13: 9781428320628, PB ©2012, 608 pages.
5. Virtual Pharmacy Externship for Technicians (CD-ROM), 1st Edition, Delmar ISBN-10: 1439057427 ISBN-13: 978143905742, CD ©2011
6. Pharmaceutical Dosage Forms: Disperse Systems, Volume 3 Informa Healthcare; 2nd edition (January 15, 1998), 559 pages.
7. Practical classes materials – http://intranet.tdmu.edu.ua/data/kafedra/internal/index.php?&path=lik_tex/classes_stud/en/pharm/prov_pharm/ptn/Pharmaceutiсal technology/3/
8. Lecture materials – http://intranet.tdmu.edu.ua/data/kafedra/internal/index.php?&path=lik_tex/lectures_stud/en/pharm/prov_pharm/ptn/Pharmaceutiсal technology/3/
9. Lecture presentations – http://intranet.tdmu.edu.ua/data/kafedra/internal/index.php?&path=lik_tex/presentations/en/pharm/prov_pharm/ptn/Pharmaceutiсal technology/3/
Discussed and adopted at chair-sitting
of department of Drugs technology
22 December 2012, minute № 7
