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Work program

June 25, 2024

TERNOPIL STATE MEDICAL UNIVERSITY

of I.Ya. Horbachevskyiy

“ CONFiRM”

Vice-rector of Studing work

Prof. I. R. Mysula

“ ” 2008

WORKING PROGRAM ON PHARMACOLOGY FOR THE STUDENTS OF DENTAL FACULTY

Course рс

Semester

Summary

Iumb.

Kind

to control

Lectures (hours.)

Practical classes

Extra-classes work

Examination

ІІ

ІІІ

162

matrikul of practical skills

–

Teacher Oleshchuk O.M made working program.

Working program was adopted at the Chair Sitting of department of pharmacology with clinical pharmacology (Minute N 13, 11.06.2008)

Head of department of pharmacology with clinical pharmacology professor K.A. Posokhova

Working program was adopted at the Chair Sitting of cyclic methodological commission of SSI of pharmacology, hygiene and medical biochemistry of M.P. Skakun (Minute N 5, 19.06.2008)

Head of cyclic methodological commission as.-prof.. O.M. Oleshchuk

TERNOPIL 2008

1. EXPLANATORY MESSAGE AND STRUCTURE OF DISCIPLINE.

In the system of higher education pharmacology is one of sciences, which binds all theoretical disciplines to practical medicine.

The course of pharmacology engulfs sections: “Medical compounding”, “General pharmacology”, “Special pharmacology”.

Qualifying description of medications, properties of medicinal preparations and methods of their implementation is fixed in basis of the program.

2. PURPOSE OF STUDY OF EDUCATIONAL DISCIPLINE.

Main task of department pharmacology to teach students to be oriented in facilities of treatment and prophylaxis of diseases of stomatologies.

In the process of studies students-stomatologies must master theoretical questions: determination of group, classification of preparations, mechanism of their action, feature of farmakokinetiki and farmakodinamiki of every preparation, effects of sides, testimonies and contra-indications, is to their setting, form of issue and dosage of basic preparations. With the purpose of control of knowledges of students and more accomplished capture of skills from excerption of recipes on all practical employments, processing of individual jobs of controls is foreseen with excerption of 3-4 recipes and decision of pharmacological tasks, built taking into account a chemical structure, farmakokinetiki, farmakodinamiki, farmakoterapii. After every section of pharmacology, with the purpose of control of knowledges and abilities from the mastered material, a thematic plan is foresee conducting of control work which is conducted in writing and includes the task of the medical compounding and decision of basic farmakoterapevtichnikh tasks with a concrete clinical situation, of the proper medications.

At the study of pharmacology students must purchase such knowledges and skills:

– to master general principles of registration of recipes and drafting of compounding samples of writing;

– able to write recipes on different medical forms.

From the section of the special pharmacology:

– able to analyse operate medicinal preparations and to estimate possibilities of their application in stomatology practice;

– able to write medications in recipes at the certain pathological states, going out from the features of farmakodinamiki and farmakokinetiki preparations.

Practical skills are purchased:

– to write in recipes medicinal preparations in different medical forms;

to use certificate literature for pharmacology.

Taking into account new organization of educational process in an university, which includes the method of the unique day and module system of studies, lecture on pharmacology will be read 1 astronomic hour and practical employments from pharmacology will pass on such chart:

– practical work of students – 3 academic hours

– seminar discussion of themes of practical employments – 3 academic hours

– test control of knowledges of students – 1 academic hour

All practical skills which a student must master it is borne in “Matrikulumu”.

At the end of every semester a student must hand (about what a teacher puts a mark) over all practical skills which studied during a semester.

3. TABLE OF CONTENTS OF PROGRAM.

Thematic Plan of Lectures in Pharmacology for the Students of Dental Faculty for the first semester of 2008-2009 academic year

№

The name of lecture

Last name of lecturer

Definition of pharmacology, subject assignment, connection with other sciences, history of development. Local anesthetics. Irritative drugs, astringent agents, adsorbents, slime agents.

prof. KA. Posokhova

Autonomic pharmacology. Inderect acting cholinergic stimulants.

Agents acting M-cholinergic receptors. Agents acting H-cholinergic receptors.

Adrenergic receptor-acting drugs (adrenomimetics, adrenoblockers, sympatholitics).

prof. KA. Posokhova

Analgesics.

prof. KA. Posokhova

General CNS depressants (neuroleptics, tranqulisers, sedative, litium salts).

Activating CNS agents.

prof. KA. Posokhova

Drugs acting on the respiratory organs function.

prof. KA. Posokhova

Plan of Practical Classes in Pharmacology for the Students of Dental Faculty

for the first semester of 2008-2009 academic year

№

The name of practical class

Amount of hours

Introduction to the medical prescription. Rules of ordering prescription. Firm medicinal forms.

Soft medicinal forms.

Liquid medicinal forms (solutions for external and inner use).

Liquid medicinal forms (infusions, decoctions, emulses, mixtures, tinctures, liquid extracts, new-Galen`s preparations)

Medicinal forms for injections.

Agents that affect the afferent innervation (local anesthetics, irritative drugs, astringent agents, adsorbents, slime agents).(Novocainum, xycainum (lidocainum), trimecainum, anaesthesinum, dicainum, ultracainum, bypivacainum, taninnum, vismuti nitras, herba Hyperici, folia Salviae, flores Chamommilae, carbo activatus, carbolenum, Enterosgelum, amilum, semenum Lini, solutio Ammonii caustici, mentholum, charta sinapis, oleum Terebinthinae rectificatum).

Anatomical and physiological peculiarities of autonomic nervous system. Indirect acting cholinergic stimulants. Cholinesterase reactivators (Proserinum, Pyridostigmini bromidum, Galanthamini hydrobromidum, Dipiroximum, Alloximum,Amizysilum, Cyclodolum).

Agents acting M-cholinergic receptors (Pilocarpini hydrochloridum, Aceclidinum, Atropini sulfas, Platyphyllini hydrotartras, Scopolamini hydrobromidum, Extractum Belladonnae siccum, Ipratropii bromidum (Atrovent), Pirensepinum (Gastrocepinum), Methacinum).

Agents acting N-cholinergic receptors. Nicotine toxicology (Benzohexonium, Pirilenum, Hygronium, Pentaminum, Tubocurarini chloridum, Pipecuronii bromide (Arduanum, Mellictinum, Dithylinum).

Adrenergic receptor-activating drugs. Adrenergic receptor-blocking drugs. Sympatholytic agents (Adrenalini hydrochloridum, Noradrenalini hydrotartras, Ephedrini hydrochloridum, Mesatonum, Naphthyzinum, Xylometasolinum, Isarinum,Salbutamolum, Fenoterolum, Fentolaminum, Prasosinum, Anaprilinum, Atenololum, Metoprololum, Talinololum, Reserpinum, Octadinum ).

General anesthetics (Aether pro narcosi, Isophluranum, Nitrogenium oxydatum, Propanididum, Ketaminum,. Thiopentalum-natrium, Natrii oxibutas).

Hypnotic agents. Antiepileptic drugs. Antiparkinsonical preparations (Teturam (dysulphiram), Phenasepamum, dipheninum, Carbamasepinum, Clopamidum, Ethosuximidum, Natrii valproas, Lamotridzin, Nitasepamum, Bromisovalum, Chlorali hydras, Zolpidem, Zopiclon, Levodopa, Midantanum, Cyclodolum).

Narcotic and non-narcotic analgesics Morphini hydrochloridum, Omnoponum, Codeini phosphas, Promedolum, Phentanylum, Pentazocini hydrichlorium, Tramadolum, Buprenorphinum, Nalorphini hydrochloridum, Naloxoni hydrochloridum, Naltrexonum, acidum acetylsalicilicum, analginum, Acidum mephenamicum, Paracetamolum, Ibuprophenum, Diclofenac-natrium, Indometacinum, Piroxicamum, Amisonum, Meloxicsm (Movalis), Celecoxib)

General CNS depressants: neuroleptics, tranquilizers, sedatives. Lithium preparations (Aminazinum, Triftazinum, Droperidolum, Haloperidolum, Closapinum, Chlorprotixenum, Sulpiridum, Phtorphenasinum, Chlozepidum, Sibasonum (Diasepanum), Phenazepamum, Medazepamum, Litii carbonas)

Activating CNS drugs: analeptics, antidepressants, metabolic cerebral protectors and adaptogens (Imisinum, Amitriptillinum, Pyrazidolum, Fluoxetinum, Sydnocarbum Coffeinum-natrii benzoas, Piracetamum, Cavintonum, Pentoxyphylline, Natrii oxybutiras, Cinarisinum, Vinpocetinum, Nicergolin, Pentoxiphyllini, papaverini hydrochloridum, Sermionum, Tinctura Ginseng, Tinctura Schisandrae, Extract Eleuterococci, Pantocrinum, Bemetilum, Cordiaminum, Sulfocamphocainum, Camphora, Bemegridum, Aethymisolum)

Drugs acting on the respiratory organs function.-1 Respiratory stimulators. Cough remedies. Expectorants. (Aethymisolum, Sulfocamphocainum, Bemegridum, Саrbogenum, Codeini phospas, Glaucinum, Oxeladinum, Libexinum, herba Thermopsidis, Radix Althaeae, Mucaltinum, Trypsinum crystallisatum, Bromhexinum, Ambroxolum, Acetylcysteinum, Ambroxolum.

Drugs acting on the respiratory organs function-2. Broncholytical preparations. Drugs used for lung edema management (Orciprenalini sulfas, Salbutamolum, Fenoterolum, Ambroxolum, Ipratropii bromidum (Atrovent), Cromolinum-sodium, Ketotifenum, Beclometasoni dypropionas, Triamcinolonum, Strophantinum, Corgliconum, Hygronium, Pentaminum, Droperidolum, Furosemidum, Mannitum, Morphini hydrochloridum, Phenthanilum, Spiritus aethylicus).

Cardiotonic drugs. Cardiac glycosides and other inotropic drugs. Agents used for treatment of congestive heart failure (Strophantinum, Corgliconum, Digoxinum, Digitoxinum, infusum herbae Adonodis vernalis, Dophaminum, Dobutaminum).

Antianginal agents(Nitroglicerinum, Sustac, Isosorbidi dinitras, Isosorbidi mononitras, Verapamilum, Amlodipinum, Anaprilinum, Atenololum, Metoprololum, Dipiridamolum, Drotaverinum (No-spanum), Validolum, Trimetasidinum, ADP-long).

Antiarrhythmic agents (Chinidini sulfas, Novocainamidum, Ethmosinum, Ajmalinum, Lidocainum, Trimecainum, Dypheninum, Aethacizinum, Propaphenolum (Rythmilen), Anaprilinum (Propranololum), Atenololum, Talinololum, Metoprololum, Amiodaronum, Verapamilum).

Antihypertensive agents (Anaprilinum (Propranololum), Atenololum, Talinololum, Metoprololum, Carvediolum, Prasosinum, Doxasosinum, Labetololum, Captoprilum (Capotenum), Enalaprilum, Lisinoprilum, Losartanum, Clopamidum,Fenigidinum, Amlodipinum, Furosemidum, Dichlothiazidum, Spironolactonum, Clophelinum, Reserpinum, Octadinum, Methyldopha, Pentoxiphyllinum Agapurinum), Diazoxidum, Natrii nitroprussidum, Drotaverinum, (No-spa), Magnesii sulfas, Dibasolum, Papaverini hydrohloridum).

Gastrointestinal agents –1. (Tinctura Absithii, herbae Centaurii, insulinum, Peritolum, Phepraninum, Masindolum, Apomorphini hydrochloridum, radix Ipecacuanae, Cupri sulfas, Triftazinum, Aethaperazinum, “Aeronum”, Metoclopramidum, (Reglan, Cerucal), Aropini sulfas, Pentagastrinum, Pepsinum, Acidum hydrochloricum dilutum, Ranitidinum, Famotidinum, Pirensepinum, Omeprasolum, Natrii hydrocarbonas, Magnesii oxydum, Aluminii hydroxydum, Almagel, Sucralfat, Vismuti dinytras, Misoprostolum).

Gastrointestinal agents –2. (Pancretinum, Mesim forte, Festal, Creon, Contrycalum, Acidum aminocapronicum, “Allocholum, Cholenzymum, Acidum chenodeoxycholicum, Magnesii sulfas, Natrii sulfas, Tabulettae radicis Rhei, cortex Frangulae, folium Sennae, Gutalax, Bisacodilum, Caphyolum, Regulax).

Diuretics (Furosemidum, Hydrochlortiazidum, Clopamidum, Acidum etacrynicum, spironolactonum, Triamterenum, Mannitum pro injectionibus, Urea pro injectionibus, herba Egusetum arvence, herba Ortosiphoni, Lespenephril). Uterine Stimulant and Relaxants (Diniprost, Diniproston, Ergometrini maleas, oxytocinum, Pituitrinum, Estron, Estradioli propionas, Proserinum, Olei Ricinum, Chininum, Tocopheroli acetas, Progesteroni acetas, Atropini sulfas, Partusistenuim (Fenoterol). Drugs used in gout and hyperuricemia (Allopurinolum, Etamidum, Urodanum, urolesanum).

List of practical skills in matrikul

№

Name of practical skill

Level of capture

Line of matrikula

To write prescription on firm medicinal forms., soft medical forms, liquid medical forms (solutions for external and internal use, medical forms for injections )

To write recipes on soft medical forms ( ointments, to pasture, linimenti, candles, gel, cream)

Thematic Plan of Lectures

PLAN OF LECTURES IN PHARMACOLOGY ON _______________ MONTH of 2009

№

Date

reading

Hour

reading

Number

Lecture-room

№№

Student groups

Scientific, last name lecturer

Theme of lecture

27.01.09

12⁵⁰ – 13⁵⁰

А₉

13, 14

prof. KA. Posokhova

Definition of pharmacology, subject assignment, connection with other sciences, history of development. Local anesthetics. Irritative drugs, astringent agents, adsorbents, slime agents.

03.02.09

12⁵⁰ – 13⁵⁰

А₉

13, 14

prof. KA. Posokhova

Autonomic pharmacology. Inderect acting cholinergic stimulants.

Agents acting M-cholinergic receptors. Agents acting H-cholinergic receptors.

Adrenergic receptor-acting drugs (adrenomimetics, adrenoblockers, sympatholitics).

17.02.09

14 ⁰⁰– 15 ⁰⁰

А₉

13, 14

prof. KA. Posokhova

Analgesics.

10.03.09

10¹⁰ – 11¹⁰

А₉

13, 14

prof. KA. Posokhova

General CNS depressants (neuroleptics, tranqulisers, sedative, litium salts).

Activating CNS agents.

24.03.09

11²⁰– 12²⁰

А₉

13, 14

prof. KA. Posokhova

Drugs acting on the respiratory organs function.

Thematic Plan of Practical Classes in Pharmacology for the Students of Dental Faculty

for the first semester of 2008-2009 academic year

№

Date

Conducting of lessons

№

groups

№ № Theme of lessons

A rank is scientific

of teacher, last name

30.01.09

2.02.09

Introduction to the medical prescription. Rules of ordering prescription. Firm medicinal forms.

As.

Chernyashova V.V.

Soft medicinal forms.

Liquid medicinal forms (solutions for external and inner use).

13.02.09

2.03.09

Liquid medicinal forms (infusions, decoctions, emulses, mixtures, tinctures, liquid extracts, new-Galen`s preparations)

As.

Chernyashova V.V.

Medicinal forms for injections.

27.02.09

1.04.09

As.

Chernyashova V.V.

Agents acting N-cholinergic receptors. Nicotine toxicology (Benzohexonium, Pirilenum, Hygronium, Pentaminum, Tubocurarini chloridum, Pipecuronii bromide (Arduanum, Mellictinum, Dithylinum).

30.03.09

28.04.09

General anesthetics (Aether pro narcosi, Isophluranum, Nitrogenium oxydatum, Propanididum, Ketaminum,. Thiopentalum-natrium, Natrii oxibutas).

As.

Chernyashova V.V.

27.04.09

25.05.09

As.

Chernyashova V.V.

22.05.09

4.06.09

As.

Chernyashova V.V.

STANDARDS OF QUESTIONS ARE FOR EXAMINATION.

1. To indicate a mechanism of antiseptical action to the permanganate potassium.

A.Oxidization of organic components of protoplasm of microorganisms.*

B. Dehydrotation of albumens of protoplasm of microorganisms.

С. Inhibit sulhydril groups of the enzymic systems of microorganisms

D. Activate of cyclooxygenase.

E. Inhibit of cyclooxygenase.

2. Specify a mean, that effective at macrocytic anaemia

A. Iron of protoxide lactase.

B. Fercovenum.

С. Epoetin beta.

Д.* Acidum folicum.

Е. Меthyluracilum.

F. Ferro-Gradumet.

3. To note the usage of ergocalciferolum.

A. Ricket.*

B. Atherosclerosis.

С. Hypovitaminosis C.

Д. Hypervitaminosis D.

Е. Hypertension.

4. Patient used glucocorticoids during a long peroid of time. After quick stopp the mialgia, weekness, emotion excitment, headache, sleeplessness, depression of appetite, nausea. The withdrowl syndrome apeare. What drug must be used in this situation?

A. АCТH

B. Glucocorticoids.*

C. Mineralocorticoids.

D. Insulin.

E. Thyroxine.

5. What is the effect, which appear after using narcotic analgesics for a long time?

A. Mental and physical dependence.*

B. Material comulation.

C. Physiological comulation.

D. Idiosyncrasy.

E. Tachiphylaxis.

5. THE CONTROL FORMS AND CRITERIA OF EVALUATION OF KNOWLEDGES ARE AT THE END OF WORKING DAY.

Knowledges of student of 3 courses are checked up and estimated as a result of eventual estimation which is middle arithmetic from estimations for every type of activity (practical work, seminar discussion of practical work and writing control). All estimations are proposed on a 12-ball scale.

In accordance with the decision of methodical conference on a department conducted:

I. Practical part of employment

1. Excerption of recipes (in accordance with the list of programmatic preparations from all themes of employment) is 6 marks.

2. To the answer for supervisory of question from all themes of employment – 6 marks.

II. A seminar discussion of practical employment is 12 marks. At the exposure of estimation for seminar part of employment activity of student is taken into account and knowledges are shown.

III. Supervisory part of employment

1. Excerption of recipes (3 things) is 3 marks (from 0 to a 1 mark for a 1 recipe)

2. Tasks (6 things) of situations are 6 marks (from 0 to a 1 mark for every task)

3. To the test of task (10 things) – 3 marks (0,3 mark for a faithful answer).

METHODICAL SUPPLYING.

1.Lectures (you can find on Web-page of lectures).

2. Methodical instructions for students (you can find on Web-page of department).

3. Methodical instructions for students independent study (you can find on Web-page of department).

7. REFERENSES

1. Pharmacology, 2nd edition, Mary J. Mycek, Richard A. Harvey, Pamela C Champe. Lippincot-Raven, 1997, 514 pages.

2. Basic and Clinical Pharmacology, 6th edition. B.Katzung. Appleton & Lange Publishers, Stamford, 1995, 1017 pages.

3. Goodman’s and Gilman’s the Pharmacological Basis of Therapeutics, 9^th edition.

J. Hardman, P. Molinoff, R.Ruddon, A.Goodman Gilman. The McGraw-Hill Companies, New-York, 1996. 1800 pages.

4. Drug Interactions: A Source Book of Adverse Interactions, their Mechanism, and Clinical Importance, 3^rd edition. I. Stockley. Blackwell Science, Malden, 1994, 932 pages.

5. Ama Drugs Evaluations. – 1998. – Ed. VIII.- 1125 p.

6. Multimedia Lecture on pharmacology to the students of 3 course of medical faculty.

7. O. Stefanov, V. Kucher Pharmacology with general prescriptiom – Kiev,2004– 150 p.

8. Posokhova K.A., Oleshchuk O.M. Rules of medical prescription writing – Ukrmedknyha,2005 – 25 p.