In 1942 V.P. Filatov formulated the doctrine about biogenic stimulators which supposed that isolated tissues of vegetative or animal origin after their acclimatization to severe surrounding conditions are subjected to biochemical reorganization in metabolic systems forming substances capable to render stimulating influence and to accelerate vital processes when administered by an organism. These substances have been named biogenic stimulators. The author emphasized two positions of the doctrine: a) formation of biogenic stimulators should be considered as the way of body adaptation to environment produced by evolution; b) biogenic stimulators are fm mod within tissues separated from an organism until these tissues are alive and are placed under extreme conditions.
The main factors causing formation of biostimulators include:
– low temperature (2-
– storage in dark place (parts of plants);
– hard work of muscles;
– x-ray irradiation.
Biogenic stimulators being entered into a “large” organism (by transplantations i tinned tissues or by injections of their extracts) will activate vital processes there.
Strengthening metabolism, they enhance physiological functions of a body; in case ol body disease – raise its resistibility and regenerative properties, promote recovery.
Chemical nature of biogenic stimulators is still not well-studied. It has been found, that at biostimulation there are deep biochemical transformations owing to which some metabolic substances accumulate and, consequently, physico-chemical parameters of extracts from animal or plant tissues change. The characteristic features of these changes include, in particular, increase in amount of water-soluble substances that indicates on autolysis.
Besides, one can observe decrease of pH value due to accumulation of acidic products; rising of oxidability and iodine-absorbing ability as a result of increase in unsaturated bonds; the increasing of amine nitrogen, especially glutamic and aspartii acids.
Sysoev A.F. found in freeze-tinned aloe leaves various organic acids: citric, malic, succinic, ribonucleic, arginine. These acids together with their sodium and potassium salts in certain concentration render stimulating action on growth of yeasi cells, raise dehydrase activity of granulating tissues and regenerating liver.
Tissue preparations of various origin by V.P. Filatov contaiumerous complex of biologically active substances. Placenta preparations (extract and suspension) contain rich and various composition of mineral and organic substances, a lot of high fat acids (palmitic, stearic, oleic), vitamins of B group, aminoacids, ketosterols and acetylcholine.
Available now data on chemical property of preparations by V.P.Filatov show, that substances various in their origin can be common for all preparations of this group – organic acids, polysaccharides; and at the same time there are also specific, individual substances. So, volatile amines are inherent to peat and peloidodistillate unlike aloe preparations; steroid hormones are only in placenta preparations.
The main objective of biostimulant manufacture is to obtain the whole complex of biologically active substances from plant or animal tissues iative (unchanged) state.
On the Odessa enterprise “Biostimulator” there are manufacturing of biogenic preparations of plant, animal and mineral origin (Biossedum, fluid aloe extract for injections and as oral solution, Peloidinum, peloidodistillate for injections, FiBS for injections, Gumisolum, placenta extract, corpus vitreum, etc.).
