Organization of work of pharmacy with commodity supplies.
1. A commodity supply and determination of current requirement in medications
A pharmacy must have an obligatory assortment of medications. It is today registered in Ukraine over 9300 names of medications and over 100 wares of the medical setting. A commodity supply is mass of medications and wares of the medical setting, which is in the field of appeal and subject realization. To the commodity supplies belong:
– commodities which are present in a presence in a pharmacy and it the separated structural subdivisions
– commodity, purchased and prepaid a pharmacy and leave on responsible storage for a supplier or those, that are in transit on the way
– commodity supplies which are handed over on processing (for example, medical digister)
Commodity supplies in a sum and in days set for every pharmacy individually. It depends on many factors – commodity turnover, top-level quantity of medicinal preparations. Surpluses of commodity supplies conduce to binding of facilities, absence of medications in a pharmacy – to the loss of the visitors. On a 5 course you will study discipline „Pharmaceutical marketing”, where in detail learn about tactic of pharmaceutical firms in relation to sale of medicines. Today we will talk about the so-called short-term planning of commodity supplies. At the pharmaceutical market of Ukraine of suggestion in relation to medications considerably prevail demand on them. Purchase power of population of Ukraine is not high. Hundreds of firms-producers, wholesale firms, daily offer to the pharmacies the wide spectrum of medications.
Determination of current requirement is in medications
For rational work pharmacy forced correctly determine a requirement in medical means and wares of the medical setting. Pharmacies, as a rule, register consumption of medications. Watch, that from each pharmacotherapeutical groups in a pharmacy were medications. On a 3th course you studied pharmacology and know, what is pharmacotherapeutical group, preparations-analogues. For determining the minimum amount of medicinal preparation of the certain name it is necessary to have the following information:
– there is (remain) an amount of preparation
– when (as often) an order recommences
– how many to order repeatedly
There are a few mathematical methods, how to expect a requirement in medications. Presently a language will go about everyday laborious job which a pharmacy must conduct, to define a requirement in medications. Idea-l’niy a variant is a computer account of receipt and consumption of commodity. A cash variant, scan-out, enables watch after a dynamics of sale and by the remain of medications. There are programs which will specify on the numbers of month when and how many it is sold. Journalize account of refuses, take into account the queries of visitors, watch after advertising. Potoschniy the account of commodity gives an oppottunity to trace what and how many are in a pharmacy, but also predict terms and volume of new procurement . For this purpose it is needed to define:
– rates of sale of medication (middle demand is for certain definite period), it depends on seasonality
– Duration of time is between verification of tailings of commodity supplies
– Backlogs of supplies
For establishment of quantitative volume orders utillize such formula:
KOZ = (PPTZ + POSES) õ of SDNP + RZ – From
where KOZ is a quantitative order of concrete preparation volume
PPTZ is periodicity of verification of commodity supplies in a pharmacy
POSES is a period of receipt of order
SDNP is an average norm of sale of medication
RZ – reserve stock
From is the forecast remain on the day of delivery
2. Task and functions of department of supplies of pharmacy
The independent department of supplies will be organized only in the pharmacies of a 1 group. In other pharmacies he is incorporated with a compounding production department.
Basic tasks the department of supplies is:
1. Reception of medicines and second commodities of pharmacy assortment, which enter pharmacy from a wholesale pharmaceutical enterprise (will make, to the factory).
2. Providing of correct storage of commodities.
3.Vacation of commodities to other departments of pharmacy, hospitals, organizations and establishments, fastened on a pharmacy on a supply.
4.Making of concentrates, ready-to-cook foods, VASES, leadthrough of laboratory- packing works.
Coming from foregoing tasks the workers of department of supplies execute the followings types of works or function:
1. Make ordering-ordering for a serve a supplier, Order-requirement takes into account demand of population on the commodities of pharmacy assortment.
2. Engaged in determination of requirement in medications at the level of pharmacy.
3. Fill glasses with medicines for an assistant room.
4. Control the terms of fitness and quality of medications.
5. Accept invoices invoice -requirements and complete ordering for the departments of pharmacy, LPU, other buyers
6.Packing works conduct laboratory.
Next to the functions listed above prepares agreeing to supplying with products.
2. Composition of premisses of department of supplies. Rational organization of workplaces
Before the apartments of department of supplies belong:
1. Purveying.
2. Packing
3. Financial rooms
4. An apartment is for maintenance of fastened to hospitals
5. room for unpacking
Organization of workplace is the system of measures on the equipment of workplace by facilities and articles of labour and placing of them in set procedure. Than workplace is better organized, the higher the labour productivity. Above all things it is necessary to be stopped for organization of workplace of pharmacist of department of supplies of, which is engaged in laboratory works and workplace of packer – executes packing works. Correct placement of his worker place is foreseen, rotator, scales, glasses with medicines, auxiliary matters. To the work place of pharmacist-technologist a pipeline must be conducted with the cleared water and set capacious burette for measurement in the distance of stretched hands . All of necessary objects are set taking into account optimum range . It is expedient to equip the table of pharmacy laboratory. For the increase of efficiency of labour recommended to use facilities of small mechanization and office equipment . Here are vehicles for grinding down and mixing of powders, magnetic mixer, electric mixer, apparatus for filtration under a vacuum, equipment of windows-sluices for passing to the products, keeping indoors outside an apartment.
3. Nomenklatrura of workers of department of supplies. Position about the workers of department.
The followings positions are foreseen in the department of supplies: pharmacist, pharmacists (technologists), packer.
Task and duties
· Carries out guidance the department of pharmacy in accordance with the current legislation of Ukraine and normatively legal acts which determine activity of organs of management and establishments of health protection organization of pharmaceutical service.
· Organizes work of department on providing of population and wholesale buyers medications and medical commodities which are subject from vacation from structural subdivision.
· Controls a presence in the department of necessary range of pharmaceutical goods and medical wares in obedience to the ratified norms.
· Creates necessary terms for storage of medicines, other medical wares, in accordance with their properties and requirements of the State pharmacopoeia.
· Inculcates the account of earnings and sale of material assets and facilities.
· Analyses the indexes of work of department, takes measures in relation to their optimization.
· Organizes workplaces and inculcates their automation.
· Develops and inculcates measures on a labour and fire-prevention defence, observance of rules of the personal and production hygiene protection.
Adheres to principles of medical deontology.
· Constantly perfects the professional level.
In the cases when in a constituent order in place of position of manager of department – a pharmacist, is entered on position of manager of department – druggist, this position operates fully.
Must know:
· is there a current legislation about a health protection and normative documents which regulate activity of organs and establishments of guard healthy?ÿ;
· organization of pharmaceutical service in the state;
· organization of work of department on providing of population and pharmacy and hospitals establishments, other wholesale buyers, by medications and commodities of the medical setting;
· technology of the individual making of medications, estimation of their quality and governed storage;
· feature of reception, storage and vacation of poison, narcotic matters, psychotropic preparations, precursors, and other medications which are subject Committee on control after the drugs of MOH of Ukraine;
· order of account of motion of the fixed and circulating assets, basis foundation of record-keeping and accounting;
· control of processes of management of pharmaceutical establishments basic links;
· organization of implementation of contractual duties;
· methods of determination of demand and calculation of requirement are in medicinal preparations and commodities of the medical setting;
· order of leadthrough of complete and having a special purpose pharmaceutical inspection;
· modern literature on speciality, methods of its analysis and generalization
Zav.viddilom submits çàâ.àïòåêîþ or to his deputy.
* Controls a presence in the department of necessary range of pharmaceutical goods and medical wares in obedience to the ratified norms
Condition about the pharmacist of pharmacy
1. Position of pharmacist is held a by a person with higher pharmaceutical education
2. Appointed and freed managers a pharmacy
3. In the work a pharmacist follows a current legislation, position about
pharmacist of pharmacy, by orders by instructions
4. In the work submits directly the manager of department
A pharmacist of department of supplies is under an obligation:
n to carry out the reception of requirements, check up the rightness of their registration, compatibility of inbox ingredients
n to conduct preparation of the concentrated solutions, ready-to-cook foods, VASES
n share work among packers and to accept the packed up products
n to stick to governed storage of medicines in financial rooms in
to strict accordance with their properties and requirements of DF, orders, instructions
n to Watch after the rightness of registration of glasses with the supplies of medicines
n renew the supplies of medicines in the departments of pharmacy
n to conduct acquisition of supplies of departments and carry out their vacation
n to watch after shelf-life the made medications, take off in a required order medications with overdue term of fitness
n to take part in folding orders on medicines
n to register list of medicines that are to be ordered
n to take part in the receipt of medicines and carry out control after their correct placing of storage
n to control the observance of health regime in the apartments of pharmacy
4. Organization of reception of commodities of pharmacy assortment
Naychastishe is carried out the last variant, but all of other are practically possible. During organization and leadthrough of acceptance of commodities it is necessary to adhere to operating THAT. Special terms of supply , instructions and position about deliveries of products of BREST and commodities of national economy..
At the зrailway station, to the water station and in an air-port a commodity is accepted after an amount by a bridge and the masses of gross (weight of commodity with packing, unlike mass without packing off – net). The state of actual presence of commodities and information of attendant letter is thus checked up – commodity bill of lading, inserts to the boxes, accompanying (packing) letters. If found out a shortage or damage of cargo , representative of pharmacies must require from a transport organization of drafting of commercial act. On the basis of commercial act in future restrictions to a transport organization or claim about the compensation of loss are produced. Commodity primage which came in uselessness through fault of transport organizatioot accepted a pharmacy.
Reception of commodity on composition of supplier or pharmaceutical enterprise representative of pharmacy or çàâ.àïòåêîþ conducts or for the amounts of commodity units and on mass net, or if a commodity is packed in boxes and other container – on a seating capacity and mass of gross, For the receipt of commodity on composition an agreement must be celled, attorney is given.
A commodity, the delivered is centralized the transport of supplier and appointed for realization in the different departments of pharmacy, is accepted the department of supplies. Commodity which acts from a supplier with his transport at first can be accepted after a seating capacity and to mass of gross.
Preliminary pharmacies give a supplier an order-requirement. A commodity accompanies a commodity bill of lading and tax invoice, conclusion in relation to quality. In an invoice specified all of essential elements of supplier and pharmacies, through whom released, by what transport, term of payment. The code of commodity, name of products, unit of account, amount, cost of producer (custom), cost of supplier, sum, is given.
Fact of reception of commodity materially responsible person confirms the culture of reception (now seal) and by the signature on all of copies of invoices.
Necessary:
-agreement
– invoice
– tax invoice
– copy of license
– payer of tax
– quality of producer certificates are on every preparation, every series
– in separate cases certificate of control-analytical laboratory
In the pharmacy of necessarily conducted acceptance for amounts and qualities. Acceptance of commodity for the amounts of units and net carried out in a pharmacy persons, which are powered by manager, in the presence of supplier or representative from public. Time of acceptance of commodity is thus marked. To the eventual acceptance commodity on mass of net and amount of commodity units must be conducted not later than 24 hours from the moment of receipt of perishable preparations and not later than 10 days from the moment of receipt of other commodities.
Authorized persons with application check amount, price, total worth of commodity, and conduct collation them with information of invoice bladding . The special attention is spared verification of amount of acceptanced commodity primage . Receiving control which consists in checking of original appearance is conducted to that end, to marking, packing, blocked of commodity. If there are doubts in quality, medications head for an analysis in EXCREMENT and for the answer of laboratory they are kept separately and will not realize. With application check terms of fitness. On medicines, a remaining term of fitness must be not less than 60%, but for bacterial preparations – a not less than 40% term of fitness which is marked on a label.
5. Organization of leadthrough of entrance control quality of medications is in pharmacies (retail business). A person, his duties, is authorized.
Entrance control of quality of medications in pharmacies carries out a person, appointed the order of leader of subject, is accountable for quality of medications which enter pharmacy (a person is authorized). The authorized person must have higher or middle pharmaceutical education. ITS last name, contact telephone for the form of connectivity (telephone, fax, electron mail) it follows to reveal to the territorial inspection. To jurisdiction of the authorized person preparation and registration of conclusion belongs in relation to the results of entrance control of quality of medications with a mark about retaking of them to realization.
The main duty of the authorized person is:
* verification of medications which enter pharmacy, and accompanying documents – invoices (with the obligatory pointing of the name, dosage, medical form, number of series, amount, name of producer), quality of producers, information, certificates about registration status of medication;
* registration of conclusion of entrance control of quality of medications;
* conduct of register of medications which acted to to subject of economic activity;
* verification of presence in the pharmacy of off-grade and falsifyed cerouss of medications is in obedience to information of territorial inspection.
* grant the territorial inspection of reports about found out off-grade and medications are falsifyed or about which suspicion is in relation to quality. Stop of trading in such medications.
* agreeing about an internal order of appeal of medications which enter pharmacy:
To buy in and get medications does it follow only in subject, what have operating licenses to a right for a wholesale. The copies of such licenses are added to the agreements about a supply and saved for the manager of pharmacy or authorized person with all of complete set of documents.
Medications are got a pharmacy must pass visual control the authorized person. Before the receipt of writing conclusion of the authorized face of trading in the got medications forbidden.
The authorized person checks up accordance of the got medications accompanying documents in relation to amount, dosage, numbers of cerouss, terms of fitness, registration status, name, medical form, producer. Every series of medications must be accompanied by conclusion in relation to quality, which seems a producer, notarized the seal of supplier.
A group container, external (secondary) and internal (primary) packing, marking, insets of sheet, original appearance, without opening of packing is checked for integrity, homogeneity, presence of damages, quality of package materials. At a necessity, if there was suspicion in relation to quality, quality of package materials. At a necessity, if suspicion is in relation to quality, medications are checked up with opening of packing in relation to sizes, form, color, homogeneity, amount of units, in packing, presence of contaminations.
At the call-sign result of entrance control the authorized person passes the got series of medications in realization.
At a negative result the authorized person makes an act about found out defects which what are foundation for returning of party to the supplier. The copy of act is given in a territorial inspection, which after the leadthrough of additional verification and selective of labtest takes measures in relation to informing of other pharmacies about found out off-grade or falsifyed medications and controls the actions of provider for their elimination, utilization or returning (in the case of off-grade cerouss) a producer.
In the case of origin of doubt in relation to quality of medications at implementation of visual control the authorized person takes away the standards of doubtful medications and sends them in a territorial inspection for passing of laboratory researches. In a time of leadthrough of such researches, to the final decision of question about quality, series of doubtful medications are in a quarantine, isolated from other medications, with denotation “Trade is prohibited to the separate order”.
5. Organization of storage of commodities of pharmacy.
Climatic requirements are to the mode of storage.
Requirements include the followings parameters: temperature, relative humidity of air, air exchange, gas composition of air and luminosity.
Temperature of storage – one of the most considerable indexes of the mode of storage. Chemical, physical and chemical, biochemical and microbiological processes increase with the increase of temperature. A temperature is measured in degrees to centigrade (0 Ñ ). A few modes of storage are foreseen.
Room temperature …………………………………+ (18 …20)
Cool temperature …………………………….+ ( 12…15)
Coolroom ……………………………….+ (4…0 )
High temperature of air ……………anymore +20
Low temperature of air ……………. 0
Other temperature terms come into a question in instruction to medications.
Relative humidity of air (GDP) is an index which characterizes the degree of saturation of air aquatic pair and measured in percents %. Evaporation of water from commodities results in quantitative and high-quality losses, mainly to by the natural loss due to a siccation and fading (drying up). In addition, humidity of air is enhanceable to microbiological waste , corrosions of metallic surfaces.
Choice of optimum GDP is determined foremost chemical composition of commodities, their hygroscopicity, temperature of storage and presence of bioshields. Relative humidity of air in a dry apartment must not exceed 60 %, and in an apartment with enhanceable moisture is 65 %.
«By the instruction is regulated for organizations terms of storage in pharmacy establishments of different groups of medicinal preparations and articles of the medical setting» (order ¹ in 44 1993) Order from March, 16, 1993 ¹ 44 ì. Kyiv
Instruction spreads on all of pharmacy establishments, instead from their department subordination and pattern of property ownership.
Arrangement, composition and sizes of apartments, for storage in pharmacy establishments must answer all of requirements of operating normatively technical document (build norms and governed, normative department document but other). An apartment for storage in obedience to the set norms is provided protective and fire-prevention facilities.
In apartments for storage a certain temperature and humidity of air must be supported, periodicity of verification of which is carried out not rarer 1 time per days. For looking after these parameters storage facilities must be provided thermometers and hygrometers which are fastened on the internal walls of depository aloof from heater devices on height of (1,5-1,7) mcode from a floor in the distance not less than 3 mcodes from doors. The map of account of temperature and relative humidity must be led in every department.
Pharmacies are equipped the devices of the central heating. Heating of apartments is shut out by gas devices with the opened flame or electrical devices with the opened electro-spiral. Apartments for storage must be provided with the necessary amount of shelvings, closets, pallets, et cetera. Establishment of shelvings is carried out thus, that they were in the distance (0,6-0,7) a mcode from external sthenes, not less than 0,5 mcodes from ceiling and no less than 0,25 mcodes are from a floor. Shelvings in relation to windows must be located so that passage-ways were lighted up, and distance between shelvings made no less 0,75 mcodes for providing of free access to the commodity. The apartments of pharmacies must be contained retained in a cleanness, the floor of apartments periodically (but not rarer once in a day) cleans up a moist method with application of the settled cleansers.
It is not recommended to dispose medications, consonant on the name alongside, medications for the internal use of list, which strongly differ higher doses, and also to dispose in alphabetical order.
In the apartments of storage medications take a place separately:
– in severe accordance with toxicological groups: list And (poisonous and narcotic matters); list (drastic matters) and general list.
Medications of lists And and must be saved in obedience to operating orders;
– in accordance with pharmacological groups;
– depending on the method of the use (internal, external);
– medications of “angro” are accordingly with the aggregate state (liquid separately from friable, gaseous et cetera);
– in accordance with physical and chemical properties of medications and influence of different factors of external environment;
– taking into account the set terms of fitness for medications;
– taking into account character of different medical forms.
It follows to keep the wares of the medical setting separately after groups:
– rubber wares;
– wares are from plastics;
– bandaging facilities and auxiliary materials;
– wares of medical technique.
In the process of storage it follows to conduct a continuous visual review on the state a container, by the external changes of medications and wares of the medical setting not rarer once in a month. At the damage of container it is necessary immediately to remove its defects of or contents to translate in other container. In the case of external changes of medications control of their quality is conducted in obedience to the requirements of DF and other NTD and their fitness is determined to the use in accordance with established procedure.
All of medications depending on physical and physical and chemical properties, action on them of various factors of external outward environment, are distributed on such:
– what require protecting from light;
– what require protecting from the action of moisture;
– what require protecting from evaporation;
– what require protecting from the action of enhanceable temperature;
– what require protecting from a mionectic temperature;
– what require protecting from the action of gases which are contained in an environment;
– fragrant, paint;
– disinfectant facilities.
To the number of medications which require protecting from light, belong: antibiotics, halenja preparations (tinctures, extracts, concentrates, are from a digister), medical digister, organo, vitamins and vitamin preparations, corticosteroids, essential oils, fat butters, drazhovani preparations , salts of iodine-, and bromystovodnevoyi acids, halenozamischeni connection, nitro-and nitrozospoluky, nitrates, nitrites, amino-and amidoconnections, phenic connections, derivates of fenotiazyna.
It follows to keep medications which need protecting from the action of light in-container from dark slide materials (to the glass container of orange glass, metalpacks, packing, from an alfol or polymeric materials, painted in a, brown br. or orange black), in a dark apartment or in closets, painted in a middle a black paint with the densely driven in doors or in the densely hammered together boxes with the densely driven in lid.
For storage of especially sensible to light medicinal matters (nitrate of silver), a glass container is pasted over a black opaque paper (medicinal matters which need action of light, for example, preparations of iron of protoxide, it follows to keep in the glass container of small capacity of light luminous glass in the bright world. The action of direct sunbeams is assumed.)
6.3. Features of storage of medications which require protecting from moisture
To medications which what require protecting from the action of moisture, belong: hygroscopic matters and preparations (for example, acetate to potassium, dry extracts, medical digister, salt nitric, nitrous, halogenhydrogen and phosphoric acids, salts of alkaloids, sodium metallo-organicss, antibiotics, enzymes, medicinal matters which are characterized after the pharmacopeia article as such, that as easy as anything dissolve in water, and also medicinal matters, maintenance of moisture of which must not exceed a level, set DF and other NTD . It follows to keep medications which require protecting from the action act of atmospheric vapor water in cool town, in the densely packed container from materials, that penetrating for vapor of water (glass, metal, alfol, to the thick-walled plastic container).
Medications with found out hygroscopic properties it follows to keep in a dry apartment in a glass container with air-tight closing , inundated from above a paraffin. At closing container with such medicinal matters it is necessary with application to wipe a neck and cork of glass. Medications of this group of, which are got in packing from polymeric tape and intended for the supply of jurisdiction pharmacy network, to keep in central district pharmacies in the factory packing, in other pharmacies it follows to translate in a glass or metallic container.
Organization of storage of such preparations requires among medications of this group of the special attention, as a gypsum is singed, mustard in powder, which at absorption of moisture transform from shallow amorphous powder in shallow grains – lose the properties virtue and become useless for the use in medical practice. To prevent spoilage:
– it follows to save a gypsum singed in the well closed container (for example, in the densely hammered together wooden boxes or barrels, it is desirable assessed inwardly intra polyethylene tape);
– mustard in powder it follows to keep in bottletight tin jars;
– mustard plasters keep in packs, cased in a sheepskin paper or polyethylene tape, what place in densely closed container (for example, cardboard boxes, pasted over inwardly polymeric tape).
6.4. Features of storage of medications which require protecting from the action of enhanceable temperature
To medications which what require protecting from the action of enhanceable temperature, belong:
– group of medications which require protecting from weathering
– fusible matters;
– bacterial preparations (vaccines, wheys, toxoids, but other);
– antibiotics;
– hormonal preparations;
– vitamins and vitamin preparations;
– preparations which contain glycosides ;
– medical fats and butters;
– ointments on fatty basis and other matters
It follows to keep medications which require protecting from the action of enhanceable temperature at a room (18-20 50 0С), cool (12-15 50 0С) temperature. The lower temperature of storage is required on occasion (for example, for ATP 3-5 50 0С, that must be it is indicated on a label or in instruction to application of preparation. It follows to keep bacterial preparations in the industrial packing separately after the names, at a temperature, indicated for every name on a label or in instruction to application.
It follows to keep antibiotics in the industrial packing at a room temperature, if other pointing absent on a label.
It follows to keep organ preperations in protected from light, cool and dry place at a temperature (0+15 50 0С), if there is not other pointing on labels or instructions to the use.
Features of storage of medications which require protecting from the action act of mionectic temperature
To the number of medications which require protecting from the action act of mionectic temperature, such the physical and chemical state of which after freezing changes and belong, at the next warming to the room temperature, does not recommence (40% sol. of formaldehyde, solutions of insulin but other)
It follows to keep 40% solution of formaldehyde (formalin) at a temperature not below +9. At appearance of sediment maintain at a room temperature, then solution carefully unite and utillize a formaldehyde in obedience to actual maintenance.
It follows to keep an icy ac.a. at a temperature not below +9. At appearance of sediment acid is maintained at a room temperature to dissolution of sediment. In the case when sediment does not dissolve, liquid part of acid protophobe is united and utillize in obedience to actual maintenance of ac.a. in preparation.
Medical fat butters require storage at a temperature not below +10 Ñ. At appearance of sediment they are maintained at a room temperature, unite and check for accordance with all of requirements of DF.
6.5. Features of storage of medical digister
A medical digister must be saved in a dry, well ventilated, apartment, in clean dry, without extraneous smells and homogeneous for for every party of raw material to the container, in pharmacies – to glass, metallic, in boxes with a lid, B/Ss paper multi-layered or tissue boxes. For packing of the packaged medical digister packs are utillized cardboard, packages are polyethylene, paper, wrappings paper.
Optimum terms for storage of medical digister are a temperature (18-20 50 0 С), humidity of air, – (30-40%).
In storage facilities raw material must be saved on shelvings which are set in the distance not less than 15 see from a floor. Optimum terms for banking are a not more than 2,5 mcode – for berries, seed, buds, not more than 4 mcodes – for leaves, flowers, herbares, more than 4 mcodes – for other types of raw material. A stack must be placed from the sthenes of composition in the distance not less than 25 see intervals between stacks not less than 80 see q.v. .
On every stack there must be a label by the size (20*10) of see with pointing of the name of raw material, enterprise-sender, year and month of purveyance, number of party, to give a receipt for plants which contain cardiac glycosides , information about biological activity.
Medical plants contain the complex of various natural matters. Quantitative advantage some from them in a plant foresees the special terms of storage of medical digister. List of raw material, classified after groups, storage and depending on character and properties of operating matters, resulted in addition 9.
A medical digister which contains essential oils is kept it is isolated in the well packed container. Some hygroscopic herbares, leaves and garden-stuffs, must be kept in a glass or metallic container to hermetically bottled and, if necessary, inundated a paraffin (for example, leaves of foxglove et al).
At storage of medical digister which contains nutritives, for prevention of spoilage of it by barn wreckers, it is recommended to dispose in the places of storage a small bottle with a chloroform in the cork of which a tube cutting-in for weathering vapor a chloroform. A chloroform is added as far as his weathering.
Ready medical vegetable collections keep in pharmacies and on pharmacy compositions (bases), adhering to the general rules. Special attention at storage it follows to spare a medical digister which contains cardiac glycosides , for what DF more severe shelf-lives are set and repeated re control on maintenance of biological activity.
A poisonous and drastic medical digister is kept in a separate apartment or in a separate closet locked up.
All of the prepared medical forms must be saved in the original packing, by a label outside. On shelvings, shelves, closets a shelving card, which the name of preparation, series, term of fitness, amount, is marked on, registers. A card is printed on a dense paper and led on every series which acts for control after its timely realization. Except for it, in a department there must be a card index after the terms of fitness. Preparations which are subject re control are saved separately from other to the receipt of results of analysis.
Pills, drops, keep it is isolated from other medical forms in the factory packing which protects from external actions and counted on vacation a separate patient and to medical establishments. Storage of pills and drops must be carried out in dry, and, if it is necessary, in the place protected from light.
Storage of greater part of preparations in the aerosol packing must be conducted at a temperature (-35 Ñ) in the dry, place protected from light, a little rather from a fire and heated devices. It follows to guard the aerosol packing from shots and mechanical damages.
Features of storage of medications and wares of the medical setting are taking into account their terms of fitness
The term of fitness is determined NTD. In obedience to operating requirements the term of fitness is specified on packing for all of medications. If in NTD on medications “Preparation is indicated controlled annually” or “Activity is controlled annually”, on packing, except for “Suitable to to…”, the proper inscription belongs.
Separate medications equally with the basic term of fitness have additional . Medications which have an additional term of fitness, upon termination of basic, re control is subject in analytical laboratory and, at the positive result of analysis, realized in obedience to the additional term of fitness . Perekontrolyu is subject also preparations in which to completion of term of fitness found out the signs of external changes.
The imported preparations of re control are not subject. The terms of fitness of medications, made in a pharmacy, are resulted in the proper documents. In the places of storage of medications for their timely realization they are disposed taking into account the remaining term of fitness.
6.6. An order of storage and conduct is in pharmacy establishments with medications and wares of the medical setting, which are inflammable and explosive characteristics
Medications and medical wares which are inflammable and explosive characteristics are widely utillized in medical practice. Wrong storage and handling afore-named medications and wares of the medical setting can be a cause of fire. Except for severe financial losses, it is possible to inflict serious harm the health of workers of pharmacy establishments.
Depending on physical and chemical properties of the adopted groups inflammable matters divide into flammable and inflammable , and explosive – on an explosion and explosive which are apt at formation of explosive mixtures and compressed gases.
Each, who acts on work, the introductory and primary instructing must pass in the workplace on questions of storage of inflammable, explosive matters, compressed gases, accident and fire safety, grant of the first aid a victim prevention, at an accident.
Not rarer once in a year it is necessary to conduct verification of knowledges for employees on questions of storage of medications, which have flammable and explosive properties, technicians of safety and fire-prevention safety. A qualifying commission is created to that end . The results of verification must be designed protocol.
Medications are inflammable and explosive it follows to keep similarities on principle, in obedience to their physical and chemical and to fires properties, packing character. To that end fireproof compositions are broken up on separate apartments (compartments), that isolated from each other blank heat-resistant walls (by partitions).
In default of separate depositories for flammable matters storage of them is assumed in general heat-resistant buildings, and also in buildings, part on a section at the obligatory isolation of apartments, allocated for storage substances from absent apartments by heat-resistant walls which answer requirements of fire hazard and concerted with the organs of Derzhpozhezhnaglyadu. Such premises must have ventilation. Necessary amount of inflammable matters for current outlays assumed to hold in the packing rooms of compositions or pharmacies, but at the severe observance of fire safety measures. Remaining amounts of inflammable matters for completion of work at the end of change return into place of basic main storage.
The floor of compositions and unloading grounds must have hard, even coverage which eliminates dints and other inequalities. Forbidden to utillize boards and ferrous letters for smoothing of floor. A floor must provide the comfortable and safe movement of people, loads and transport vehicles, simplicity and lightness of cleaning up of storage facilities.
Forbidden to realize from a pharmacy medications with overdue term of fitness.
For made shelf-lives are set in the pharmacy of medical:
n hydrogens solutions which contain benzylpenitsylin , glucose, – 1
n eye drops, mucuses, – 2
n emulsions, suspensions – 3
n other medicinal forms – 10 days
Solutions under rolling – 2
7. Registration of vacation of material assets to the departments of pharmacy, retail network , hospitals
From the department of supplies in other departments of pharmacy, hospitals and organizations, also in the fastened net a commodity is released after the invoice-requirement of AP-16. A date is specified in an invoice ¹ commission. In invoices-requirements the name of poisons, narcotic matters, alcohol ethyl, specified a latin language. Except for it, the superimposed requirements on poisons, drugs and alcohol, must be written on separate forms. They must have a stamp of LPU, seal and signature of leader of establishment.
Invoices for hospitals in 3 copies, 1 with a commodity report is passed in accounting , second a buyer for payment, third – to recipient . On medicines, that are in ammount-quantitive account – in 4, the last remains – for a materially responsible person which released.
Additions
Addition 1
Instruction is for organizations of storage in pharmacy establishments of different groups of medications and articles of the medical setting
It is ratified the order of Ministry of health Ukraine from 16.03.1993 N 44
1. Prelimpages.
1.1. This instruction sets requirements to organization of storage of different groups of medications and articles of the medical setting in pharmacy establishments.
1.2. Instruction spreads on all of pharmacy establishments, regardless of their department subordination and pattern form of property ownership.
1.3. Requirements, set this instruction, are duties at planning and building of new firsttime , reconstruction and exploitation of operating pharmacy establishments.
2. Requirements are to arrangement and exploitation of apartments for storage.
2.1. Arrangement, composition and sizes of apartments, for storage in pharmacy establishments must require to all of requirements of operating normatively technical document (build norms and governed, normative department document).
2.2. Arrangement, equipment and exploitations of apartments, for storage must provide storage of medications and wares of the medical setting.
2.3. An apartment for storage in obedience to the set norms is provided protective and fire-prevention facilities.
2.4. In apartments for storage must be supported certain temperature and humidity of air, periodicity of verification of which is carried out not rarer 1 time per days. For looking after these parameters storage facilities it is necessary will provide
by thermometers and hygrometers which are fastened on the internal walls of depository aloof from heater devices on height of (1.5-1.7) mcode from a floor and distance no less 3 mcodes from doors. The map of account of temperature and relative humidity must be led in every department.
2.5. For maintenance of cleanness of air of apartment for providing in obedience to an operating normatively technical document it follows to equip reveal-drawing ventilation with a mechanical motive. In the case when it is impossible to equip an apartment for
storage reveal-drawing ventilation, it is recommended to do accomplish small hinge window pane, transoms, second grate doors and all that.
2.6. Pharmacy compositions and pharmacies are equipped the devices of the central heating. Heating of apartments is shut out by gas devices with the opened flame or еlectric devices with the opened electro-spiral.
2.7. On compositions (bases) and in pharmacies, located in a climatic area zone with large deviation from the possible norms of temperature and relative humidity of air, apartment, for storage must be equipped conditioners.
2.8. Apartments for storage must be provided with the necessary amount quantity of shelvings, closets, pallets. Establishment of shelvings is carried out thus, that they were in the distance (0.6-0.7) a mcode from external sthenes, not less than 0.5 mcodes from ceiling and no less than 0.25 mcodes are from a floor. Shelvings according to windows must be located so that passage-ways were lighted up, and distance between shelvings made no less 0.75 mcodes for providing of free access to the commodity.
2.9. The apartments of pharmacy compositions (bases) and pharmacies must be contained in a cleanness, the floor of apartments periodically (but not rarer thin once in a day) cleans up a moist method with application of the settled cleansers.
3. General requirements are to organization, storage of medications and wares of the medical setting
3.1. Medications and wares of the medical setting in the apartments of storage it is necessary to dispose taking into account the most complete use of areas, creation of the best terms of labour, for pharmacy workers, possibility of application of facilities
mechanizations and providing of pharmaceutical order.
3.2. It follows to dispose medications and wares of the medical setting on shelvings, in closets, and, if necessary, on the floor, special tile.
3.3. It is not recommended to dispose medications, consonant on the name alongside, medications for the internal use of list, which strongly differ higher doses, and also to dispose in alphabetical order.
3.4. In apartments storages of medications take a place separately:
– in severe accordance with toxicological groups: list And (poisonous and narcotic matters); list (potent matters) and general list.
Medications of lists But also must be saved in obedience to operating orders;
– in accordance with pharmacological groups;
– depending on the method of the use (internal, external);
– medications of “angro” are accordingly with the aggregate state (liquid separately from friable, gaseous et al);
– in accordance with physical and chemical properties of medications and influence of different factors of external environment;
– taking into account the set terms of fitness for medications;
– taking into account character of different medical forms.
3.5. It follows to keep the wares of the medical setting separately after groups:
– rubber wares;
– wares are from plastics;
– bandaging facilities and auxiliary materials;
– wares of medical technique.
3.6. In the process of storage it follows to conduct a continuous visual review on the state a container, by the external changes of medications and wares of the medical setting not rarer once in a month. At the damage of container it is necessary immediately to remove its defects or maintenance
to translate in other container. In case of external changes of medications control of their quality is conducted in obedience to the requirements of state pharmacopoeia by normatively technical documents and their fitness is determined to the use in accordance with established procedure.
3.7. In the apartments of storage, and also on territory of composition (bases) it is necessary systematic conducts the measures of fight against rodents, insects and other wreckers.
4. Requirements which are produced to storage of different groups of medications and wares of the medical setting
All of medications depending on physical and physical and chemical properties, distributed an action on them of various factors of external outward environment on such:
– what require protecting from light;
– what require protecting from the action of moisture;
– what require protecting from evaporation;
– what require protecting from the action of enhanceable temperature;
– what require protecting from a law temperature;
– what require protecting from the action of gases which are contained in surrounding environment;
– fragrant, paint;
– bleach facilities.
In appendixes to this instruction the lists of medications of the above-stated groups are resulted with pointing of requirements of storage economy .
Lists are oriented and include medications are more frequent all applied in pharmacy establishments. Medicinal preparations which did not enter in these lists must be saved taking into account their physical and chemical properties in obedience to the requirements of the State pharmacopoeia and other normatively technical document.
4.1. Features of storage of medications which require protecting from light.
4.1.1. To the number of medications which require protecting from light, belong: antibiotics, halenja preparations (tinctures Tinctura , extracts, concentrates, are from vegetable wares), medical digister, organ preparations, vitamins and vitamin preparations, essential oils, fat butters, salt of iodine- and bromidehydrogenium acids, amidoconnections, phenic connections, derivates of phenothiazine. More frequent all common in pharmacy practice medications of this group are given in addition of N 1.
4.1.2. It follows to keep medications which need protecting from the action of light in-container from dark slide materials (to the glass container of оrange glass, metalpacks, packing, from an alfol or polymeric materials, painted in black, brown
or orange color), in a dark DK apartment or in closets, painted within by a black paint and with the densely driven in doors or in the densely hammered together boxes from densely by a adjusted lid.
4.1.3. For storage of especially sensible to light medicinal matters (nitrate of silver), a glass container is pasted over a black opaque paper. Medicinal matters which need action of light, for example, preparations of iron of protoxide. it follows
to keep in the glass container of small capacity of light glass in the bright world. The action of direct sunbeams is assumed.
4.2. Features of storage of medications which require protecting from moisture.
4.2.1. To medications which require protecting from the action of moisture, belong: hygroscopic matters and preparations (for example, acetate to potassium, dry extracts, medical digister, salt nitric, nitrous, galogenohydrogenium and phosphoric acids, salts of alkaloids, sodium metallo-organicss, glycosides, antibiotics, enzymes, dry organ preparations, medicinal matters which are characterized after the pharmacopeia article as such, that as easy as anything dissolve in water, and also medicinal matters, maintenance of moisture of which must not exceed a level, set the State pharmacopoeia and other normatively technical document (addition of N 2).
4.2.2. It follows to keep medications which require protecting from the action of atmospheric vapor water in a cool place, in the densely packed container from materials, that penetrating for vapor water (glass, metal, alfol foil , to the thick-walled plastic container).
4.2.3. Medications with found out hygroscopic properties (given in addition of N 2) it follows to keep in a dry apartment in a glass container with air-tight closing, inundated from above a paraffin. At closing container with such medicinal matters it is necessary with application to wipe a neck and cork of glass.
4.2.4. Medications of this group of, which are got in packing from polymeric tape and intended for the supply of jurisdiction pharmacy network, to keep in central district pharmacies in the factory packing, in other pharmacies it follows to translate in glass or metal container.
4.2.5. Organization of storage of such preparations requires among medications of this group of special , as a gypsum is singed, mustard in powder, which at absorption of moisture transform from shallow amorphous powder in shallow grains – lose it
properties and become useless for the use in medical practice. To prevent spoilage:
– it follows to save the gypsum of burnt in the well closed container (for example, in the densely tight hammered together wooden boxes , it is desirable assessed within by polyethylene tape);
– mustard in powder it follows to keep in bottletight tin jars;
– mustard plasters keep in packs, cased in a parchment paper or polyethylene tape, which place in densely closed container (for example, cardboard boxes CH , pasted over within by polymeric tape).
4.3. Features of storage of medications which require protecting from weathering (evaporation).
4.3.1. To the number of medications which require protecting from weathering, belong:
– actually volatiles which are more frequent all used in pharmacy practice (resulted in addition of N 3);
– medicinal preparations which have a volatile solvent (alcoholic infusions , liquid alcoholic concentrates, thick extracts);
– solutions and mixtures of volatiles (essential oils, solutions of ammonia, formaldehyde, chlorous hydrogen, over 13 %, carbolic acid, ethyl spirit of different concentration et al);
– medical digister which contains essential oils;
– medicinal preparations, what contain crystallizational water – crystallohydrates (addition of N 4);
– medicinal matters which are laid out with formation of volatile products (Iodoformium, peroxydum hydrogen, Chloraminum, hydrocarbonas of sodium);
– medicinal matters with set a normatively technical document by the lower level of maintenance of moisture (sulfate of magnesium magnezium , paraaminosalicylas sodium, sulfate of sodium et al);
4.3.2. It follows to keep medications which require protecting from evaporation in a cool place, in hermetically to the closed container with penetrating for the volatiles of materials (glass, metal, alfol). Application of polymeric container, packing, and closing is assumed in obedience to the State pharmacopoeia and other normatively technical document.
4.4.4. Crystallohydrates, depending on relative moisture of air, can show properties virtue of both hygroscopic and drivings, matters, that is why it follows to keep them in hermetically closed to glass, metallic, or thick-walled plastic a container at relative humidity of air (50-65 %) in a cool place.
4.5. Osovblivosti of storage of medications which require protecting from the action act of enhanceable temperature.
4.5.1. To medications which require protecting from the action of enhanceable temperature, belong:
– group of medications which require protecting from weathering (see a section 4.3 of given instructions);
– fusible matters;
– bacterial preparations (vaccines, wheys, toxoids et al);
– antibiotics;
– organ preparations;
– hormonal preparations;
– vitamins and vitamin preparations;
– preparations which contain glycosides;
– medical fats and butters;
– ointments on fatty basis and other matters (addition of N 5).
4.5.2. It follows to keep medications which require protecting from the action of enhanceable temperature at a room temperature (18-20 hail.Ñ, to cool (12-15 hail.Ñ to the temperature). The lower temperature of storage is required on occasion (for example, for ATP (3-5 hail.Ñ), that must be it is indicated specified on a label or in instruction to application of preparation.
4.5.3. It follows to keep bacterial preparations in the industrial packing separately after the names, at a temperature, indicated specified for every name on a label or in instruction to application.
4.5.4. Bacterial preparations of the the same name keep save on series, taking into account the term of their fitness.
4.5.5. Bacterial preparations in the process of storage are subject a visual review not rarer than one time in 3 months.
4.5.6. It follows to keep antibiotics in the industrial packing at a room temperature, if other pointing absent on a label.
4.5.7. It follows to keep organ preparations in protected from light, cool and dry place at a temperature (0+15 hail.Ñ), if there is not other pointing on labels or instructions to to
use.
4.5.8. A liquid Chisel requires storage in a cool place. At dimness solution is filtered and check up falling short of all of requirements of the State pharmacopoeia. Allowed opalescence of solution.
4.6. Features of storage of medicinal facilities which require protecting from the action of mionectic temperature
4.6.1.To the number of medications which require protecting from the action act of mionectic temperature, such the physical and chemical state of which after freezing changes and at the next warming to the room temperature does not recommence belong (40 % sol. of formaldehyde, solutions of insulin but other).
4.6.2. 40 % it follows to keep solution of formaldehyde (formalin) at a temperature not below +9 hail. S. Pri it is maintained appearance of sediment at a room temperature, then solution is carefully united and utillize in obedience to actual maintenance of formaldehyde.
4.6.3. It follows to keep an icy ac.a. at a temperature not below +9 hail. Ñ. At appearance of sediment acid is maintained at a room temperature to dissolution of sediment dregginess . In the case when sediment of not dissolved , liquid part of acid is united and utillize in obedience to actual maintenance of ac.a. in preparation.
4.6.4. Medical fat butters require storage at a temperature not below +10 hail. S. Pri to appearance of sediment they are maintained at a room temperature, unite that check not
accordance is with all of requirements of the State pharmacopoeia.
4.7. Features of storage of medications, which require protecting from the action act of gases which are contained in an environment
4.7.1. To the group of medications, which change under act of gases, which are in an environment, belong:
– matters. what react with oxygen of air, different connections of aliphatic row with the unsaturated intercarbon copulas truss , cyclic with lateral aliphatic groups, with the unsaturated intercarbon copulas, phenic and polyphenolic , Morphinum and his derivates with unsubstituted for hydroxy-groups; heterogeneous and heterocyclic connections with maintenance of sulphur, enzymes;
– matters, which react with carbon dioxide of air, salt of alkaline metals and weak organic organo acids (for example, hexenalum et cetera), preparations which contain polyatomic amins (for example, еуфілін); oxydum and peroxydum magnesium, caustic soda et al (Addition of N 6).
4.7.2. It follows to keep medications which require protecting from the action act of gases in hermetically to the closed container from materials, proof for gases, on possibility potentialitie filled to the edges.
4.7.3. It follows to keep medications which easily oxidize oxygen of air in a dry apartment in a glass container with air-tight closing, inundated a paraffin.
4.7.4. It follows to turn the special attention on conditioning storage of natrii salts of malonurea, which must be kept in hermetically to the closed container, to inundated a paraffin, from materials, proof for atmospheric vapor water and carbonate
to gas.
4.8. Features of storage of fragrant and paint medications
4.8.1. The group of fragrant medications is made by matters and preparations both volatile, and practically non-flying which have a strong smell (addition of N 7).
4.8.2. Matters, their solutions, mixtures, belong to the group of medications of paint, preparations et cetera, which abandon the painted track on a container, stoppings up facilities, equipment and other objects, that is not washed off ordinary sanitary-hygenic treatment (Brilliant green, methylene blue, indigo carmine et al) (addition of N 8).
4.8.3. It follows to keep fragrant medications it is isolated in a bottletight container, proof for a smell, separately after the names.
4.8.4. Medications of paint must be kept in the special closet in densely to the closed container, separately after the names. For work with the matters of paint for every name it is necessary to select the special scales, spatula and other inventory.
4.9. Features of storage of medical digister
4.9.1. A medical digister must be saved in dry, well the ventilated apartment, in clean dry, without extraneous smells and homogenous for every party to raw material to the container, in pharmacies – to glass, metallic, in boxes with a lid, B/Ss paper multi-layered or tissue, boxes. For packing of the packaged medical digister packs are utillized cardboard, packages are polyethylene, paper wrappings the paper.
Optimum terms for storage of medical digister temperature (18-20 hail.Ñ ), humidity of air, – (30-40 %).
4.9.2. In storage facilities raw material must be saved on shelvings which are set in the distance not less than 15 see from a floor. Optimalni of condition for banking – a not more than 2.5 mcode – for berries, seed, buds, not more than 4 mcodes – for leaves, flowers, herbares, more than 4 mcodes – for other types of raw material. A stack must be placed from sthenes in the distance not less than 25 see, intervals between stacks not less than 80 see.
4.9.3. On every stack there must be a label by the size (20*10) of see with pointing of the name of raw material, enterprise-sender, year and month of purveyance, number of party, to give earnings for plants which contain cardiac glycosides, information about biological activity.
4.9.4. Medical plants contain the complex of various natural matters. Quantitative advantage some from them in a plant foresees the special terms of storage of medical digister. List of raw material, classified after groups, storage and depending on character and properties of operating matters, resulted in addition of N 9.
4.9.5. A medical digister which contains essential oils is kept it is isolated in the well packed container.
4.9.6. Some hygroscopic herbares, leaves and garden-stuffs, must be kept in a glass or metallic container to hermetically bottled and, if necessary, inundated a paraffin (for example, leaves of foxglove et al).
4.9.7. At storage of medical digister which contains nutritives, for prevention of spoilage of it by barn wreckers, recommended to dispose in the places of storage a small bottle with a chloroform in the cork of which a tube cutting-in for weathering vapor a chloroform. A chloroform is added as far as his weathering.
4.9.8. Ready medical vegetable collections keep in pharmacies and on pharmacy compositions (bases), adhering to the general rules.
4.9.9. Special attention at storage it follows to spare a medical digister which contains cardiac глікозили for which the State pharmacopoeia more severe shelf-lives are set and repeated переконтролю on maintenance of biological activity.
4.9.10. A poisonous and drastic medical digister is kept in a separate apartment or in a separate closet locked up.
4.9.11. A medical digister is subject periodic control concordantly by the requirements of the State pharmacopoeia.
Grass, roots, seed, garden-stuffs, which lost the normal colouring, smell and necessary amount of operating matters, and also staggered mould, spoilt barn wreckers depending on to the level of defeat or scrap, or after processing utillize.
4.10. Features of storage of the prepared medical forms.
4.10.1. Storage of the prepared medical forms must require to the requirements of State Pharmacopoeia and all of general requirements of this instruction, which behave to storage of medications taking into account properties of ingredients, that included in their composition.
All of the prepared medical forms must be saved in the original packing, by a label outside. On shelvings, shelves, closets a shelving card, which the name of preparation, series, term of fitness, amount, is marked on, registers. A card is printed on a dense paper and led on every series which acts for control after its realization. Except for it, there must be a card index by the terms of fitness in a department. Preparations what, re-control is subject saved separately from other to the receipt of results of analysis.
4.10.2. Pills, drops, keep it is isolated from other medical forms in the factory packing which protects from external actions and counted on vacation a separate patient and to medical establishments. Storage of pills and drops must be carried out in dry, and, if it is necessary, in the place protected from light ligth .
4.10.3. Annually pills, a drop must be checked for disintegration. In order to avoid disintegration of understrata of pills under weight of overhead, packing mass must not exceed 3 kg
4.10.4. Medical forms for injections it follows to keep in the cool, place protected from light in a separate closet or isolated apartment taking into account the features of container, if there is not other pointing on packing.
4.10.5. Liquid medical forms ( syrups, tinctures ) must be saved kept in hermetically closed, to the container filled up to the top in the cool, place protected from light. At storage of tinctures fallouts which fall out filter, and, if filtered
a tincture after quality control answers the operating requirements of the State pharmacopoeia, it is considered suitable.
4.10.6. Plazmozamischuyuchi and detoxification solutions keep it is isolated at a temperature scope from ( 0-40 ) 0С in the place protected from light.
4.10.7. Extracts keep in a glass container, by a packed screwed lid and cork with a gasket in the place protected from light. Liquid and thick extracts keep save at the temperature ( 12-15 ) of 0С. Fallouts which fall out in liquid extracts in course of time filter and, if extracts after verification answer the requirements of the State pharmacopoeia, they are considered suitable.
4.10.8. Ointments, liniments keep in the cool, place protected from light in the densely bottled container. At a necessity a condition storages combine depending on properties of ingredients. For example, preparations which have volatile and thermo labile matters in the composition keep at a temperature not higher 10 0С.
4.10.9. Storage of suppositorium must be carried out in the dry, cool, place protected from light.
4.10.10. Storage of majority of part of preparations in the aerosol packing must be conducted at a temperature ( 3-35 0С) in dry, secure from light place, a little rather from a fire and heated devices. Aerosol packing it follows from shots and mechanical damages.
4.11. Features of storage of medications and wares of the medical setting are taking into account their terms of fitness.
4.11.1. Medicines and wares of the medical setting have a term of fitness, that term during which they keep save a therapeutic effect and are in terms, that to the requirements of operating normatively technical document.
4.11.2. The term of fitness is determined a normatively technical document. In obedience to operating requirements the term of fitness is specified on packing for all of medications. If in a normatively technical document on medications “Activity is controlled annually”, on packing, except for “Suitable to to..”, the proper inscription belongs.
Separate medications equally with the basic term of fitness have additional. Likarsbki facilities which have an additional term of fitness, upon termination of basic re-control is subject in a control-analytical laboratory and at the positive result of analysis realized in obedience to the additional term of fitness. Perekontrolyu is subject also preparations in which to completion of term of fitness found out the signs of external
changes.
4.11.3. The imported preparations of re-control are not subject. The terms of fitness of medications, made in a pharmacy, are resulted in the proper documents.
4.11.4. In the places of storage of medications for their timely realization they are disposed taking into account the remaining term of fitness.
5. General rules of preparation of medications and wares of the medical setting purpose are to the use after storage economy
5.1. All of medications of “angro” before their use must be mixed. It follows to turn the special attention on displacement of overhead and wall layers of medication with other his mass.
5.2. In the case of change of maintenance of operating matters, atmospheric moisture caused a persorption or desorbtion, or by evaporation of solvent without the chemical curriculum of ingredients ( hydrolysis, oxidization, fotodestruction , et cetera ), assumed to do a count on actual maintenance of operating matters in medications at their processing in ready-to-cook foods or medications are ready.
5.3. It follows to release hardwares from wrapping and clean from butter.
5.4. It follows to add polymeric ( rubber and plastic ) wares sanitary-hygenic treatment, in obedience to the operating methodical pointing.
6. Dezinfikuyuchi facilities.
Dezinfkuyuchi it follows to keep facilities ( Chloraminum et al ) in the hermetically bottled container, in the place protected from light in the isolated apartment, a little rather from apartments for storage of plastic, rubber and metallic metallical wares, apartments, for the receipt of water of cleared.
7. Storage of wares of the medical setting.
7.1. Rubber wares.
7.1.1. For safety of rubber wares it is necessary to create in the apartments of storage:
– protecting from light, especially direct sunbeams, high ( more than 20 0С ) and low ( below 0 0С ) the temperature of air; fluid air (mechanical ventilation );
mechanical damages ( compression, bending, wring, drawing out );
– for warning of drying out, deformation and loss of their elasticity, relative humidity no less 65 %;
– isolation from the action of matters ( iodine, chloroform, ammonium chloride, лізол, formalin, acids, organic solvents, lubricating butters, meadows, Chloraminum );
– terms of storage are in the distance from heater devices ( no less a 1 mcode ).
7.1.2. An apartment for storage economy of rubber wares is needed to be placed not on a sun side, better in semi-base dark or black-out apartments. For maintenance in the dry apartments of enhanceable humidity it is recommended to put a vessel from 2 % by water solution of carbolic acid.
7.1.3. In apartments, closets it is recommended to put stage vessels with a carbonate ammonium which is instrumental in storage of elasticity of rubber.
7.1.4. Premices for storage of rubber wares is equipped, by boxes, shelves, shelvings, blocks for an increase, bars and other necessary inventory, taking into account free access.
7.1.5. At placing of rubber wares in an apartment for storage it is necessary fully to utillize all of his volume. It prevents harmful influence of surplus oxygen of air. Rubber wares ( except for corks ) caot be concluded in a few glowed, so as objects which are in understrata are squeezed and sticked. Closets for storage of rubber wares must have doors are densely tight closed. Vseredeni of closet must have fully smooth
surface. Internal arrangement of closets depends on rubber wares which are saved there. Closets are intended for:
– storage of rubber wares, in recumbency (catheters, bubbles, is for ice, glove ) equipped sliding boxes with such calculation, that it is possible it was to place objects at full length, freely, shutting out their bends, flattening, wring;
– storage of wares in the enhanceable state ( plaits, probes), hangers is equipped, located under the lid of closet. Pegs must be removable with that they can it was be taken out with the suspended objects. For strengthening of pegs
a protective strap is set with a coulisse.
7.1.6. Rubber wares place in depositories after the names and terms of fitness on every party of rubber wares tag with pointing of the name, term of fitness.
7.1.7. It follows to spare the special attention attn. storage of some types of rubber wares which require the special terms of storage:
– circles skid, hot-water bottles are rubber, bubbles for ice it follows to keep with the corks set on ends;
– removable rubber parts of devices must be saved separately from parts, done from other material;
– wares, especially sensible to the atmospheric factors, are elastic catheters, gloves, stall , bandages rubber keep in a involute kind, poured talc on all of length;
– Rubberized fabric (one-sided and bilateral) is kept it is isolated from matters, indicated in ï.7.1.1., in horizontal position in rolls, suspended on the special bars. It is allowed to keep rubberized fabric, celled no more, than in 5 times on smoothly shelves of shelvings;
– the elastic lacquered wares are catheters, probes unlike rubber keep in a dry apartment. The sign of senescence are some
softening influence, stickiness of surface. Such wares scrap.
7.1.8. Rubber wares must be periodically examined. Objects which begin to lose elasticity must be in good time picked up a thread in accordance with the requirements of normatively technical document.
7.1.9. Rubber wares must be saved packed in obedience to the requirements of operating tts.
7.1.10. Rubber gloves of recommended, if they hardened, and became fragile, to put, not straightening, on 15 minutes in warm 5 % solution of ammonia, then gloves stick and dip immerse on 15 minutes in warm (40-50 degree.C) water from 5 % by glycerin. Gloves
again become elastic.
8. Plastic wares
Wares from plastics it follows to keep save in the ventilated dark, dry apartment at a room temperature in the distance no less than a 1 mcode is from the heated devices. In an apartment it must not be the opened fire, парів volatiles. Elektropriladi and switches
must be made in an antispark (to fire-prevention) implementation. In an apartment, where the cellophane are saved, to the cellon celon , celluloid, to the aminoplastic wares, it follows to support relative humidity of air not higher 65 %.
9. Bandaging wares and auxiliary material
9.1. Bandaging wares keep in the dry ventilated apartment in closets, boxes, on shelvings and pallets which must be painted within by a light oily paint and contained in a cleanness.
Closets, where bandaging materials are, periodically wipe 0.2 % by solution of Chloraminum or chloric lime.
9.2. Sterile bandaging material (bandages, gauze serviettes, cotton wool) is kept in the factory packing. Their storage is forbidden in the primitive exposed packing.
9.3. Non-sterile bandaging material (cotton wool, gauze) is kept cased in a dense paper (B/Ss) on shelvings or pallets.
9.4. Auxiliary material (filtration paper, paper capsules et al ) must be kept in the industrial packing in the dry ventilated apartments in separate closets in severely hygienical terms. After opening of the industrial packing (capsules are a paper et al ) of packaged or it is recommended to keep a remaining amount in, paper polybags or B/Ss from kraft paper .
10. Medical leeches
10.1. An apartment for storage of medical leeches must be light, odourless medications. Shut out sharp fluctuations in a temperature, so as it causes death of leeches.
10.2. To hold leeches in a pharmacy it is necessary in the wide-mouthed glass vessels from a calculation 3 ë of water on 50-100 individuals.
For warning of proliferation of leeches tableware is covered a dense calico serviette or double layer of gauze and tightly tie around string or elastic.
10.3. Water for maintenance of leeches must be clean, free from to the chlorine, peroxidation connections, salts of heavy metals, mechanical contaminations, to have a room temperature. Water it is necessary daily to change in tableware, providing it preliminary, 2 days prior to the use. Changing water, the walls of vessel wash from middle, then neck vessels cover with gauze and through it inundate water. A vessel is filled clean water on 1/3 jars.
The table of contents of leeches requires the observance of maximal cleanness, neighbourhood is shut out them from похучими and by poisonous matters. At the disease of leeches (languor) water is changed twice on a day.
11. Requirements are to the container for medications and wares of the medical setting
11.1. It follows to keep medications and wares of the medical setting and transport in the primary, second, group transport container, foreseen an operating normatively technical document on medications and wares of the medical setting, and also on a container, packing, stoppings up facilities and order of their application.
11.2. In the case of re-packaging of industrial products, medicines, packed in the primary packing from polymeric tapes or paper, preliminary it follows to collect in groups, which must be cased in the second packing which protects from exchange of moisture or to the interchange of gases with an atmosphere (package from polymeric tape or combined materials, cardboard box with internal polyethylene coverage et cetera). It follows to pack volatile, fragrant, poisonous medications no more one name in one transport container (box, box, drum).
All of types of primary container and packing must be pressurized by application of the proper complete set of stoppings up facilities (lids of that which screwed with a gasket or cork, lid of bent , cork, metallic disperser with a cork) or by the methods of the without sealing pressurizing.
11.3. A transport container must protect the cased medications from the action of atmospheric sediment and dust, sun irradiation, mechanical damages.
11.4. A container for medical leeches sanguisuga must provide access of air.
11.5. In the case of absence of NTD on a container, packing or closing for medications or at presence of the opposite pointing at the choice of container, packing, and closing it follows to follow this instruction.
References:
1. Materials lectures .
2. MoH Ukraine of 31.10.2011 № 723 “On approval of the licensing conditions of the business of drug manufacturing , wholesale and retail sale of medicines .”
3. MOH of Ukraine of 11.07.2012 , № 515 “On Amendments to license conditions for the business of drug manufacturing , wholesale , retail, pharmaceuticals ‘
4. MOH of Ukraine of 28.10.02 , № 385 “On approval of list of health ” I health , medical , provizorskyh positions and positions for junior specialists in pharmaceutical education in health care . “
5. MOH of Ukraine of March 16, 1993 № 44 “On the organization of storage in pharmacies different groups of medicines and products of medical purpose “
6. MOH of Ukraine of 30.10.2001 № 436 ” Instruction on the procedure for quality control of medicines during the wholesale and retail sale .”
7. MOH of Ukraine of 21.01.2010 № 11 On approval of the narcotic drugs, psychotropic substances and precursors in healthcare Ukraine
8. Ministry of Health of 18.11.2010 , № 1006 ” On approval of the register of wholesale prices of medicines and the procedure for its amendment and declaration form changes the wholesale price of a drug “
